Contribution to the Study of The Antipyretic Effects of Aqueous Extracts of Two Plants « Urtica dioica and Nerium oleander ».

Document Type : Original Article


1 Department of Exact Sciences, Normal Higher School, Bechar- 08000, Algeria.

2 Phytochemistry and Organic Synthesis Laboratory, Bechar- 08000, Algeria

3 Laboratory of Pharmacognosy, Bio toxicology, and Biological Valorization of Plants, Moulay Tahar University, BP 20000, Saida, Algeria.

4 Laboratory of Process, materials and environmental engineering, Djillali Liabes University, BP 22000, Sidi-Bel-Abbes, Algeria

5 Laboratory for Experimental Biotoxicology of Biodepollution and Phytoremediation, University of Oran Ahmed Ben Bella 1. Algeria.


The current treatment of febrile conditions involves non-steroidal anti-inflammatory drugs (NSAIDs), which are widely prescribed because of their efficacy in the management of pain, fever, and inflammation. However, their long-term therapeutic use is often associated with adverse effects such as gastrointestinal ulcers. Therefore, current research is based on the substitution of chemical treatments with natural treatments that are equally effective but have fewer side effects. One of the most widespread remedies is the use of substances of plant origin. Urtica dioica and Nerium oleander are two medicinal plants widely used for the treatment of various diseases in traditional medicine. The aim of this study was to evaluate the antipyretic effect of the aqueous extract of these plants in vivo. The administration of these extracts significantly reduced brewer's yeast-induced hyperthermia. The results of this study contribute to validating the medicinal virtues of these plants, especially in the treatment of febrile states. The phytochemical constituents are probably responsible for their pharmacological properties and could replace some drugs as they cause undesirable side effects.