1-Preparation, Characterization, and Efficiency of Loading Leiurus quinquestriatus Venom on Chitosan Nanoparticles Extracted from Some Scorpions .

Document Type : Original Article

Authors

Zoology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt

Abstract

Aim: This investigation aims to extract chitin and chitosan from the three scorpions: Leiurus quinquestriatus (LQ), Androctonus crassicauda (AC) and Androctonus amoreuxi (AA) for the first time and to determine the loading capacity and efficiency of LQ venom-loaded chitosan nanoparticles (V-CN). Methods: chitin was extracted and converted to chitosan which is converted to nanoparticles (Cs-NPs) by ball-milling technique. LQ venom was collected, characterized, and loaded on Cs-NPs via the ionic gelation method. Different techniques were used to characterize the obtained compounds. Results: the dried powder of LQ, AC, and AA contained 19.7 %, 15.4 %, and 15 % chitin, respectively. FT-IR confirmed the successful preparation of chitin, chitosan, and V-CN samples. Loading capacity reached 76.50 %, while encapsulation efficiency reached 87.98 %. Conclusion: scorpion venom was effectively loaded on chitosan samples. Its physical and compound qualities, specifically, were viewed as great for biomedical and drug applications.

Keywords

Egyptian Academic Journal of Biological Sciences, B. Zoology
Volume 14, Issue 2
December 2022
Pages 373-396

Files

Share

How to cite

Statistics