Protective Effects of Androctonus Amoreuxi Scorpion Extract and Sitagliptin Treatment on The Liver Injury of Diabetic Rats

Document Type : Original Article


1 Zoology Department, Faculty of Science, Suez University

2 Pathology Department, National Research Center

3 Faculty of Science, Cairo University

4 Zoology Department, Faculty of Science, Suez Canal University


Liver injury is involved in both the pathogenesis and complications of diabetes. Androctonus Amoreuxi scorpion tea was previously reported to modulate physiological responses in streptozotocin-induced diabetic rats. This study attempts to evaluate liver protective effects of scorpion tea (Androctonus Amoreuxi) and sit agliptinin streptozotocin-induced diabetic rats. Forty rats were divided into four groups (n=10). Diabetes were induced in male albino rat by intraperitoneal injection of 65 mg/kg STZ. Three days later, the animals randomly divided to 3 groups: diabetic group, diabetic+ S.Tea(300 mg/kg )and diabetic+ ST (10 mg/kg ) besides control group received intraperitoneal injection of saline. Liver histological and biochemical markers, were monitored at the end of experimental peroid. Results of our study revealed that treatment with scorpion tea or sitagliptin produced significant liver protection manifested by a significant decrease in serum levels of alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamy-ltransferase (GGT) and lactate dehydrogenase (LDH).Histologically, liver of diabetic rats showed severe liver injury.  Histopathological changes were significantly attenuated in diabetic animals treated with scorpion tea or sitagliptin. Results of this study suggest that A. amoreuxi scorpion extract and sitagliptin have protective effects against hepatic injury.