The Effects of Androctonus Amoreuxi Scorpion Extract and Sitagliptin in the Treatment of Diabetes Mellitus type 2 in Animal Models

Document Type : Original Article


1 Pathology Department, National Research Center

2 Zoology Department, Faculty of Science, Suez University

3 Zoology Department, Faculty of Science, Suez University.

4 Egyptian environmental affair agency (EEAA) Suez.


Diabetes mellitus (DM) is a common disorder associated with markedly increased morbidity and mortality rate. The purpose of the present study is to investigate the effect of daily administration of Androctonus (A.) amoreuxi scorpion extract and sitagliptin (Januvia) on blood glucose level, glycated hemoglobin and lipid profile as well as histopathological and immunohistochemical studies of pancreas in diabetic rats forty male albino rats (130-150 gm) were divided into four notequal groups: control, streptozotocin nicotinamide (STZ/NA) induced diabetic (DM) , diabetic rats treated with sitagliptin (DM+ST) and diabetic rats treated with scorpion extract (DM+Sc.Tea).  Thirty days post ST and Sc. Tea administration (10 and 200 mg/kg B.Wt. respectively), biochemical and histological parameters were investigated.  Diabetic rats exhibited significant increase in fasting blood sugar (FBS) , glycated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), and a decrease in the level of high density lipoprotein (HDL). The administration of ST and Sc.Tea had shown significant decrease in FBS, HbA1c, TC and TG. However, a significant increase in HDL-cholesterol was recorded. Additionally, the beneficial effect of A. amoreuxi scorpion extract and sitagliptin was confirmed with histopathological examination of pancreas. Results of this study suggest that A. amoreuxi scorpion extract and sitagliptin have protective and anti-hyperglycemic effects.