Document Type : Original Article
Authors
1
Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
2
Centre of Excellence in Bionanoscience, King Abdulaziz University, Jeddah, Saudi Arabia.
3
Princess Dr. Najla Bint Saud Al Saud Distinguished Research Centre for Biotechnology, King Abdulaziz University, Jeddah, Saudi Arabia.
10.21608/eajbsz.2025.460587
Abstract
Thioacetamide (TAA) is a strong hepatotoxin that causes hepatocellular necrosis, apoptosis, pathological extracellular matrix fibrosis, and elevated levels of oxidative stress. Persea americana (P. americana) is a dietary palm fruit, it is well-known for its antioxidant properties, high monounsaturated fat content, and various other health benefits. This study aimed to evaluate the hepatic and antioxidant effects of P. americana oil in TAA-induced liver damage. Biochemical analysis, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total protein, total bilirubin, albumin, glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT), alongside the histological examination for liver tissue. Biochemical analysis of the blood serum showed that TAA exposure impaired liver function, as evidenced by elevations in the activities of ALT, AST, and ALP, total bilirubin, and antioxidant biomarkers, along with reductions in serum albumin and antioxidant enzyme activities. Treatment with P. americana oil effectively normalizes serum hepatic markers, with significant reductions in MDA, and elevations in GSH, CAT and SOD levels. Histopathological examination revealed that P. americana oil treatment was hepatoprotective with improved architecture, decreased hepatocyte degeneration, and maintained sinusoidal integrity in treated groups. These findings underscore that P. americana oil may serve as a therapeutic agent for oxidative stress-related hepatic disorders.
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