In vivo Appraisal of the Impact of Oral Using of Monosodium Glutamate on Male and Female Rats

Document Type : Original Article

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Zoology Department, Women’s College for Arts, Science and Education, Ain Shams University, Cairo, Egypt.

Abstract

One of the many adverse consequences of monosodium glutamate (MSG), a common flavor enhancer, is swelling of the cartilage. Inflammation in articular cartilage was assessed in the current investigation after MSG administration, which may have contributed to the alterations in oxidative stress indicators and articular cartilage histology seen in the animals. In this work, two primary groups of forty-two Swiss albino rats, male and female, were used. The first group's male and female rats were given distilled water orally as their control. The male and female groups of rats in the second group were given oral monosodium glutamate at a high dose of 7g/kg b.wt For a duration of two months. A notable change in histology of chondrocytes in the joints of male and female rats stained using hematoxylin-eosin and Masson trichrome stains. A significant boost in IF-gamma and IL-6 as well as a dramatic reduction in IL-4 levels in treated animals versus control. A slight elevation of sodium level and significant raise of potassium levels in animals groups consumed MSG. Furthermore, a significant rise in ALT, MDA and creatinine levels in the treated animals as well as dramatic reduction in catalase level in the treated animals versus control.  The sequence of oxidative stress development and inflammatory cytokine expression in the animals suggests that MSG-induced cellular oxidation stress in the rat cartilage tissues may have led to inflammation and cartilage matrix disintegration.

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