Therapeutic Role of Low Doses of Gamma Irradiation on Ehrlich Carcinoma Bearing Mice

Document Type : Original Article

Authors

1 Zoology department, Faculty of Women for Arts, Science and Education, Ain Shams University.

2 National Center for Radiation Biology – Egyptian Atomic Authority, Cairo, Egypt.

Abstract

Cancer is a significant reason for death globally, emerging as the second most common cause of mortality worldwide. Ehrlich ascites carcinoma (EAC) cells are investigational tumor models used globally in cancer research. Radiation therapy is commonly applied to cancerous tumors because of its ability to control cell growth. This study aims to explore the potential therapeutic effects of Low Doses of Gamma Irradiation (γ-radiation) on Ehrlich carcinoma-bearing mice. Forty adult female Swiss albino mice were divided into four groups: Normal control group (NC) of 10 mice were given saline; Ehrlich carcinoma group (EC) of 10 mice were intramuscularly inoculated with 0.2ml of EAC containing 2.5x106 in the right thigh of the lower limb of female mice; Tumor-bearing EC-Irradiated group (EC-IR) of 10 mice were exposed to 0.5Gy of gamma radiation two times weekly for 2 weeks; Radiation group (IR) of 10 mice were exposed to 0.5 Gy of gamma radiation two times weekly for 2 weeks. The current result showed a significant increment in muscle size of the right thigh, MDA, H2O2, TNF-α, IL-6, VEGF, WBC, and Platelets (PLT). Also, EC causes a reduction of antioxidant enzymes (GSH), RBCs and Heamoglobin (Hb). However, the therapeutic group (EC-IR) showed an improvement in biochemical and hematological parameters. 

Keywords

Files

Share

How to cite

Statistics