Therapeutic Role of Nanocurcumin Versus Monosodium Glutamate Toxicity

Document Type : Original Article

Authors

1 Zoology department, Faculty of Women for Arts, Science and Education, Ain Shams University.

2 Cardiac Surgery, The National Heart Institute

Abstract

The use of Nanoparticles (NPs) and nanostructured materials (NSMs) consider a new light in the progress of disease-modifying treatments for many pathological disorders. The present study is an attempt to investigate the curative effect of Nanocurcumin against long-term MSG- administration on rat liver. A total of 40 adult male Wistar albino rats were divided into the following groups: Control group (C) of 14 rats given saline; Nanocurcumin (Nano-Cur) control group of 14 rats inoculated orally with Nano-Cur (100mg/Kg b.wt/day)for 8 weeks; Monosodium group received MSG 10 mg/kg /b. w. for eight weeks; the therapeutic group was first given MSG alone for 4 weeks and was secondly administered Nano-Cur for 4 weeks. At the end of 8 weeks, animals were sacrificed by ether inhalation anesthesia where blood and liver tissues were collected to study biochemical parameters.MSG administration exerted significant elevation of cholesterol, TG, HDL, LDL, VLDL and MDA. Also showed an increase in liver enzymes. On the other hand, in the therapeutic group, Nano-Cur showed significant improvement in the previous parameters. 

Keywords

Egyptian Academic Journal of Biological Sciences, B. Zoology
Volume 14, Issue 1
January 2022
Pages 55-65

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