Modulatory Effect of Camellia Sinensis Extract on the Function of Hypothalamic-Pituitary-Testicular Axis in PTZ-Induced Epileptic Seizures in Rat Model

Document Type : Original Article


Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt


Exposure to pentylenetetrazole (PTZ) is capable of inducing experimental epilepsy in rats. This study aimed to investigate the role of Camellia sinensis extract in ameliorating the toxicity induced by epilepsy. The treatment with the extract started orally in epileptic rats after intraperitoneal injection with PTZ for 30 days (300mg/kg). Induction of epilepsy resulted in a significant decrease in glutamate, aspartate, serine, 5-HT, DA, NE and a significant increase in GABA, glycine and taurine in the hypothalamus. In addition, it causes an increase in serum LH and FSH and a significant decrease in serum testosterone in addition to disturbance in oxidative and antioxidant system. Treatment with Camellia sinensis extract showed significant improvement in most of the studied parameters at PCamellia sinensis extract exerts an ameliorative effect on the function of the hypothalamic-pituitary-testicular axis in the rat model of epilepsy.