Chromosomal Aberrations Due to Acrylamide Exposure and The Protective Role of L-arginine in Bone Marrow Cells of Male Albino Rats.

Document Type : Original Article


Zoology Department, Faculty of Science, Zagazig University, Egypt


Acrylamide (Acr) is a human carcinogen which generated in foodstuffs rich with carbohydrates during overheating. It has been recorded to induce carcinogenic and genotoxic effects in experimental animals. So, the present work aimed to evaluate the genotoxic effect of Acr and the possible protective role of L-arginine (amino acid) against Acr genotoxicity using the chromosomal aberration assay in male albino rats (Rattus norvegicus). In the current investigation, 20 male albino rats were equally divided into four main groups (n = 5); Group1 (control): Animals were received the ordinary water and diet. Group2 (L- arginine): Animals were given L- arginine at a dose of 200mg/kg/day for a month by oral gavage. Group3 (acrylamide): Animals were given Acr at a dose of 50mg/kg/day for a month by oral gavage. Group4 (Acrylymide+ L-arginine): Animals were given Arc (50mg/kg/day) together with L-arginine (200mg/kg/day) for a month by oral gavage. The results of the present work concluded that Acr is a genotoxic agent, it induced a significant increase in the frequency of total chromosomal aberrations (numerical and structural). L-arginine provides a protective potential against genotoxicity induced by Acr and this was supported by a significant reduction in the frequency of chromosomal aberrations although, the value remained higher and significant as compared with control group.