Ameliorative Effect of Cinnamon against Hypercholesterolemia Induced by High-Fat Diet in The Adult Male Albino Rat's Adrenal Gland; Histological, Ultrastructural, and Immunohistochemical Studies
Obesity is a global health issue of great concern. It leads to hyperplasia, hypertrophy of adipocytes, and metabolic complications including coronary artery disease, and cerebrovascular disease. The effectiveness of cinnamon zeylanicum as a medicinal herb comes from its anti-inflammatory and antioxidant properties. The purpose of this study was to assess the potential beneficial effects of cinnamon on adrenal toxicity caused by a high-fat diet in male albino rats. Four equal groups of the experimental animals were used, the control group, the cinnamon group, the high-fat diet group, the high-fat diet, and the cinnamon group. Animals fed cinnamon showed similar results with the control group. The adrenal cortex sections of high-fat diet-fed animals showed different degenerative changes in all layers of the adrenal gland, cortex, medulla, and corrugation of the capsule. Ultra structurally, a lot of adrenal cortical cells appeared with irregular pyknotic nuclei, swollen mitochondria, dilated sER, and numerous lipid droplets with variable shapes and sizes. Moreover, a significant rise in the immunohistochemical expression of cytochrome c in a large number of cortical cells was observed. On the contrary, animals given cinnamon and a high-fat diet exhibited noticeable improvement in the structure of the adrenal gland, and the immunohistochemical expression of cytochrome c was observed in the third group. The histological structure of the adrenal gland appeared to be mostly the same as the control one. Cinnamonhas a potential effect in improving adrenal toxicity against a high-fat diet because of the natural constituent capable of its pharmaceutical effects.
Kandil, E., Arisha, S., & Saif, M. (2024). Ameliorative Effect of Cinnamon against Hypercholesterolemia Induced by High-Fat Diet in The Adult Male Albino Rat's Adrenal Gland; Histological, Ultrastructural, and Immunohistochemical Studies. Egyptian Academic Journal of Biological Sciences, B. Zoology, 16(1), 47-64. doi: 10.21608/eajbsz.2024.344611
MLA
Eman H. Kandil; Samah M. Arisha; Mona E. Saif. "Ameliorative Effect of Cinnamon against Hypercholesterolemia Induced by High-Fat Diet in The Adult Male Albino Rat's Adrenal Gland; Histological, Ultrastructural, and Immunohistochemical Studies". Egyptian Academic Journal of Biological Sciences, B. Zoology, 16, 1, 2024, 47-64. doi: 10.21608/eajbsz.2024.344611
HARVARD
Kandil, E., Arisha, S., Saif, M. (2024). 'Ameliorative Effect of Cinnamon against Hypercholesterolemia Induced by High-Fat Diet in The Adult Male Albino Rat's Adrenal Gland; Histological, Ultrastructural, and Immunohistochemical Studies', Egyptian Academic Journal of Biological Sciences, B. Zoology, 16(1), pp. 47-64. doi: 10.21608/eajbsz.2024.344611
VANCOUVER
Kandil, E., Arisha, S., Saif, M. Ameliorative Effect of Cinnamon against Hypercholesterolemia Induced by High-Fat Diet in The Adult Male Albino Rat's Adrenal Gland; Histological, Ultrastructural, and Immunohistochemical Studies. Egyptian Academic Journal of Biological Sciences, B. Zoology, 2024; 16(1): 47-64. doi: 10.21608/eajbsz.2024.344611